MOTS-C Pen

Origin & Classification

MOTS-C (mitochondrial open reading frame of the 12S rRNA type-c) is a mitochondrial-derived peptide consisting of 16 amino acids. It is encoded by a short open reading frame within the 12S rRNA gene of mitochondrial DNA and is translated in the cytosol. Synthetic MOTS-C used in research is produced by solid-phase peptide synthesis and belongs to the class of mitochondria-derived signaling peptides.

Mechanism & Research Context

MOTS-C translocates to the nucleus and interacts with transcription factors to regulate the expression of genes involved in metabolic homeostasis. Research has demonstrated that MOTS-C influences AMP-activated protein kinase (AMPK) signaling, folate metabolism, and oxidative stress responses. It is of interest for its potential role in adapting cells to metabolic stress by modulating pathways that integrate nutrient status, insulin sensitivity, and mitochondrial function. Researchers explore how MOTS-C affects mitochondrial biogenesis, reactive oxygen species detoxification, and gene expression programs associated with ageing and metabolic disorders. The peptide is also used as a tool to investigate cross-talk between mitochondrial signals and nuclear gene networks.

Composition & Quality

MOTS-C is supplied as a compounded, ready-to-use solution with a purity typically above 95 %, verified by HPLC and mass spectrometry. Production adheres to GMP-aligned procedures, and quality control includes confirmation of sequence, analysis of impurities, endotoxin testing, and sterility assessment. The compounded solution should be stored refrigerated per provided guidelines. Certificates of analysis provide detailed characterization, including molecular mass, purity, and recommended storage conditions.

Summary & Unified Disclaimer

This description summarizes the scientific context of the molecule. It is provided for educational and research discussion purposes only. It is not intended to diagnose, treat, cure, or prevent any disease, and no medical or consumption claims are made.