Follistatin (FLGR242) – 10MG

Origin & Classification

FLGR242 is a modified form of follistatin, a glycoprotein that naturally binds and neutralizes members of the TGF-beta superfamily such as activin and myostatin. The FLGR242 variant is recombinantly engineered to include specific linker sequences and an albumin-binding domain, significantly extending its half-life in circulation compared with wild-type follistatin. It is produced using mammalian cell expression systems, resulting in a glycosylated protein of approximately 40 kDa that falls within the class of recombinant binding proteins.

Mechanism & Research Context

Follistatin acts as a high-affinity antagonist for activins and myostatin, modulating signaling through type II serine/threonine kinase receptors and downstream SMAD transcription factors. Researchers use FLGR242 to investigate how sustained neutralization of activin and myostatin affects cellular differentiation, muscle fiber growth, reproductive signaling, and inflammatory pathways. Studies explore cross-talk with BMP signaling, insulin-like growth factor pathways, and metabolic regulators. Because FLGR242 has enhanced albumin binding, it permits examination of long-term modulation of TGF-beta family signaling in vivo and in vitro, providing insight into skeletal muscle physiology, folliculogenesis, and systemic metabolism without implying therapeutic use.

Composition & Quality

FLGR242 is supplied as a lyophilized recombinant protein or sterile filtered solution. Production under GMP-aligned processes includes mammalian cell culture, purification via affinity and size-exclusion chromatography, and formulation in stabilizing buffers. Quality control entails SDS-PAGE, Western blotting to confirm the presence of the albumin-binding domain, glycosylation analysis, and assays for binding affinity to activin A and myostatin. Purity typically exceeds 95 % by HPLC, and endotoxin levels are kept below acceptable thresholds. Certificates of analysis provide detailed characterization and storage recommendations.

Summary & Unified Disclaimer

This description summarizes the scientific context of the molecule. It is provided for educational and research discussion purposes only. It is not intended to diagnose, treat, cure, or prevent any disease, and no medical or consumption claims are made.