Selank

Origin & Classification

Selank is a heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from tuftsin, an immunomodulatory peptide produced from the Fc fragment of immunoglobulin G. The addition of proline residues confers increased stability and altered receptor interactions. Selank is synthesized using solid-phase peptide synthesis and is classified as a synthetic neuropeptide with potential modulatory effects on immune and nervous systems.

Mechanism & Research Context

Selank has been reported to influence the expression of genes related to monoamine neurotransmission and immune function. Research explores its interaction with receptors such as the benzodiazepine site of GABA_A receptors, where it may modulate chloride channel activity, and potential effects on neurotrophic factor expression. Studies also examine how Selank influences cytokine production and immune cell function, including interactions with enkephalin and tuftsin receptors. Investigations aim to understand its anxiolytic-like signaling through modulation of the serotonergic and dopaminergic systems, and its regulatory effects on cytokine balance. All research is focused on mechanistic understanding of neuroimmune interactions rather than clinical outcomes.

Composition & Quality

Selank is provided as a lyophilized peptide with purity exceeding 95 %, as verified by HPLC and mass spectrometry. The peptide is synthesized in GMP-aligned facilities, followed by quality assessments including identity confirmation, endotoxin testing, and sterility checks. Selank is stable when stored desiccated at low temperature; reconstitution in sterile water or saline is recommended for experimental use. Certificates of analysis accompany each lot, detailing sequence, purity, and storage guidelines.

Summary & Unified Disclaimer

This description summarizes the scientific context of the molecule. It is provided for educational and research discussion purposes only. It is not intended to diagnose, treat, cure, or prevent any disease, and no medical or consumption claims are made.